George-Opuda et al. JOBASFUD_2025_4_2_006
Keywords: Curcuma longa, Soot, liver, Renal, Ameliorative
2026-01-31 DOI: JOBASFUD_2025_4_2_006
Background: Crude oil soot, a by product of incomplete combustion of fossil fuel, contains toxic compounds that can disrupt the liver and its functions. Curcuma longa is a medicinal plant with potential antioxidant, anti-inflammatory and regenerative effects. This study aimed to determine ameliorative potential of Curcuma longa rhizome extract against hepatorenal toxicity induced by crude oil soot in male Wistar rats. Methods: Thirty five male Wistar rats divided into seven groups namely control, soot exposed for 7, 14 and 28 days were compared with rats pre-treated with 500mg/kg of C. longa before exposure to soot for 7, 14 and 28 days respectively. Blood samples were collected and estimated for sodium, potassium, urea, Chloride, bicarbonate, creatinine, Alanine amino transaminase (ALT), Aspartate amino transaminase (AST), alkaline phosphatase (ALP), bilirubin and total protein using standard methods. Data were analysed using Statistical tool such as analysis of variance and Tukey multicomparism. Results: There was significant difference (P<0.05) in activities of ALT (U/L, AST (U/L) ALP (U/L) in Soot days 7, 14, 28, Soot and C. longa treated days 7, 14 and 28 compared with their respective control. The result showed significant difference (P<0.05) in concentrations of total bilirubin, total protein. urea (mmol/L), creatinine (µmol/L), sodium (mmol/L), potassium (Mmol/L), Chloride (Mmol/L) and bicarbonate (Mmol/L) in Soot exposed at days 7, 14, 28, Soot and C. longa treated days 7, 14 and 28 compared with their respective controls. Conclusion: The study showed that Curcuma longa rhizome extract ameliorate the hepatorenal damage caused by soot exposure.